Medizin
A novel biomarker for a reliable diagnosis of colorectal cancer based on differentially methylated genomic regions
Ref.-Nr.: 0301-4550-LI
Medizin : Diagnostika
With approximately 600,000 deaths annually colorectal cancer (CRC) is one of the most common cancer types worldwide. Early cancer and pre-cancer (polyps) detection by colonoscopy over the age of 50 until now is the best strategy for disease control and the chance of the cancer to be curable. Epigenetic changes such as DNA methylation has been shown to occur already at early stages of tumor development making such differentially methylated regions (DMRs) highly attractive for biomarker development ...
A novel strategy for reducing inflammation by modulating immune cell metabolism
Ref.-Nr.: 0106-5185-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions
Weiterlesen … A novel strategy for reducing inflammation by modulating immune cell metabolism
A predictive 3D multi-scale model of bile flux in the liver lobe
Ref.-Nr.: 1305-5341-MSG
IT / Software / Bioinformatik : Bioinformatik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).
Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...
Weiterlesen … A predictive 3D multi-scale model of bile flux in the liver lobe
Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Ref.-Nr.: 0305-3252-LI
Medizin : Therapeutika
Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. B.anthracis can cause human disease via the gastrointestinal, cutaneous or inhalational routes. There is still a considerably high rate of mortality from inhalational anthrax of up to 75 percent, even though fluorquinolone class antibiotics (e.g., ciprofloxacin) are being administered as a first-line therapy. This strategy, in addition, is being threatened by the spread of plasmid-mediated ...
Weiterlesen … Alpha-defensins (HNPs) Effectively Inhibit Anthrax-related Toxemia
Coupling part
Ref.-Nr.: 0704-5610-BC
Medizin : Diagnostika
Sensoren, Geräte und Komponenten
Diese neuartige schraubenfreie Kupplung, die auch als Überlastungskupplung eingesetzt werden kann, bietet die Möglichkeit ohne zusätzliches Werkzeug zwei drehbare Elemente auch unter extrem engen Bedingungen, spielfrei und kraftschlüssig mit hoher Präzision miteinander zu verbinden. Bisher auf dem Markt bekannte Kupplungen sind aufgrund ihrer Größe für Anwendungen im Bereich der Elektronik, der Optik, der Messtechnik sowie der Präzisionstechnik ungeeignet. Wohingegen dank der neuen Technologie, ...
New KDAC assay and selection system
Ref.-Nr.: 0803-5480-MSG
Analytik
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Diagnostika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Protein (bezogen)
Extremely sensitive, reliable and fast novel KDAC assay, which can be performed in a continuous format. This novel KDAC assay is based on Firefly luciferase harboring an acetylation on an essential active site lysine, incorporated by genetic code expansion. We furthermore offer a bacterial selection system for KDACs, which uses a reporter enzyme inactivated by lysine modifications at an essential active site residue, thereby linking deacetylase activity to a selectable output.
Newly identified subpopulation of NK cells with the promise to treat obesity and insulin resistance
0802-5237-MSG
Medizin : Therapeutika
Medizin : Diagnostika
An new approach for treatment of obesity and insulin resistance, that relies on selective ablation of a unique, previously uncharacterized subpopulation of myeloid NK cells.
Novel antiviral therapy against HIV-1 and alphaviruses: reducing frameshifting by increasing tRNALeu concentrations
Ref.-Nr.: 0707-5639-MG
Prozesse und Methoden (inkl. Screening) : Lebens-Wissenschaften (inkl. Screening)
Medizin : Therapeutika
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Nukleinsäure (bezogen)
Antiviral therapy against retroviruses and alphaviruses using tRNALeu(UUA) overexpression
Novel Biomarkers for Ageing and Metabolic Health
Ref.-Nr.: 1013-5354-MSG
Analytik
Medizin : Therapeutika
Medizin : Diagnostika
Forschungs-Reagenzien : Andere
Nukleinsäure-, Protein-, Zell-bezogene Technologien : Zellen (bezogen)
Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.
Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...
Weiterlesen … Novel Biomarkers for Ageing and Metabolic Health
Novel glycan markers for diagnosis and vaccine against toxoplasmosis
Ref.-Nr.: 0401-4561-MG
Medizin : Diagnostika
Synthetic Glycosylphosphatidylinositols (GPIs) with high selectivity and purity for Toxoplasmosis diagnosis and vaccine.
Weiterlesen … Novel glycan markers for diagnosis and vaccine against toxoplasmosis