Medizin

Cholestatic liver diseases are a heterogeneous group of disorders resulting from genetic, metabolic and congenital defects, as well as DILI (drug-induced liver injury, a leading cause of attrition during drug development).

Current diagnostic techniques for DILI and cholestasis are based on the detection of serum markers and imaging methods such as computer tomography. However, these have a low resolution and only provide a limited understanding of the underlying disease etiology. Therapeutic ...

Diese neuartige schraubenfreie Kupplung, die auch als Überlastungskupplung eingesetzt werden kann, bietet die Möglichkeit ohne zusätzliches Werkzeug zwei drehbare Elemente auch unter extrem engen Bedingungen, spielfrei und kraftschlüssig mit hoher Präzision miteinander zu verbinden. Bisher auf dem Markt bekannte Kupplungen sind aufgrund ihrer Größe für Anwendungen im Bereich der Elektronik, der Optik, der Messtechnik sowie der Präzisionstechnik ungeeignet. Wohingegen dank der neuen Technologie, ...

An new approach for treatment of obesity and insulin resistance, that relies on selective ablation of a unique, previously uncharacterized subpopulation of myeloid NK cells.

Biomarkers of ageing have long been sought after to help assess the biological age and general health status of individuals. Considerable efforts have been invested to identify such biomarkers, including physiologic readouts, metabolic parameters, glycomic profiles and others. Nevertheless, markers with strong predictive power have remained elusive.

Work in model organisms has identified several conserved signaling pathways that extend life span, such as reduced insulin/IGF signaling and ...