Prozesse und Methoden (inkl. Screening)

Remodeling the morphology of mitochondria to manipulate immune cell metabolism and hence reduce immune cell activation and effector functions

Noble metals are used in various fields of application such as catalysis, jewelry, high technology electronic equipment, equipment for glass industry and many others. As noble metals are rare and hard to extract from the ores or exhausted compounds, many efforts have been undertaken to establish an efficient recycling process. Due to their corrosion resistant properties, noble metals recycling by means of dissolution is limited to the usage of very reactive and harmful chemicals such as Aqua Regia. ...

We offer novel phosphenium ligands and corresponding metal complexes (both air stable) that are claimed as substances by granted EP and US patents. The ligands can be prepared in multigram scale by simple direct condensation. The corresponding gold complexes are suitable as homogeneous catalysts in organic synthesis (such as cycloisomerization) that can be easily precipitated and recycled due to their salt properties.

The CRISPR-Cas system is a powerful tool for site-specific genome editing. The Cas9endonuclease is capable of introducing DNA double strand breaks at a desired location withhigh precision. The lesion is repaired either in an errorprone process leading to gene inactivation or in a highly accurate way relying on an external template. Modification of the template may serve to introduce selected mutations, modified sequencesorentirely new genes.The accurate pathway comes with low endogenous efficiency. ...

File no.: MI-1012-4430-LI-ZE
(liked to MI-1012-5677-LI-ZE describing the generation of human neural microtissues from NECS cells)

A novel precursor population that forms electrophysiologically functional neurons more quickly than protocols starting with hPSCs.

Antiviral therapy against retroviruses and alphaviruses using tRNA^Leu(UUA) overexpression

Scientists in the group of Atmospheric Chemistry at the Max Planck Institute for Chemistry in Mainz have developed a novel thiosulfate based ozone scrubber to ensure accurate measurements of trace analytes. It is known from the literature that commercial potassium iodide (KI) containing ozone scrubbers can cause errors in the measurement of carbonyl compounds such as aldehydes and ketones due to byproducts formed from the oxidation of KI. Commercial ozone scrubbers based on sodium thiosulfate ...

SUMOvera enables versatile purification strategies for broad applications in eukaryotic hosts.